BioMeca was born from the meeting of two biologists, curious and convinced of the need to cross points of view and disciplines to better understand biological processes and diseases. Our expertise is in the field of the nano-mechanical and nano-structural characterization of biological materials, which allowed us to be asked for many prestigious collaborations (i.e. Ecole Normale Supérieure, France; Caltech, USA; Univ. Cambridge, UK...). For 13 years, team's members developped powerful biophysical methodologies (atomic force microscopy, nanoindentation...) suitable for in vitro, in situ and in vivo studies to characterize live cells, tissues and organs. Today we propose our knowledge and our expertise to answer your analytical requirements in life science.
- Sassi M, Ali O, Boudon F, Cloarec G, Abad U, Cellier C, Chen X, Gilles B, Milani P, Friml J, Vernoux T, Godin C, Hamant O, Traas J. « An auxin-mediated shift toward growth isotropy promotes organ formation at the shoot meristem in Arabidopsis ». Curr Biol. 2014 Oct 6;24(19):2335-42.
- Sampathkumar A, Krupinski P, Wightman R, Milani P, Jönsson H, Boudaoud A, Hamant O, Meyerowitz EM. “Subcellular and supracellular mechanical stress prescribes cytoskeleton behavior in Arabidopsis cotyledon pavement cells”. Elife. 2014 Apr 16;3:e01967.
- Milani P, Mirabet Vincent, Cellier Coralie, Hamant Olivier, Pradeep Das, Arezki Boudaoud. “Cell identities correlate with mechanical identities in plant meristems” Plant Physiol. 2014 Jun 12;165(4):1399-1408 4.
- Slade A, Milani P, Boudaoud A, Hamant O, Berquand A, Pittenger B “Investigating Cell Mechanics with Atomic Force Microscopy”. Microscopy & Analysis. Avril 2013 .
- Pittenger B, Slade A, Berquand A (Bruker Nano Surfaces) and Milani P, Boudaoud A, Hamant O (Ecole Normale Superieure de Lyon, France)“ Toward Quantitative Nanomechanical Measurements on Live Cells with PeakForce QNM “ Bruker Application Note #141 .
- Milani P, Braybrook S, Boudaoud A. “Shrinking the hammer: micromechanical approaches to morphogenesis”. J. Exp.Bot. 2013 Nov;64(15):4651-62.
- Milani P, Marilley M, Sanchez-Sevilla A, Imbert J, Vaillant C, Argoul F, Egly JM, Rocca-Serra J, A. Arneodo.“Structure and dynamics of the IL-2RA gene promoter revealed by modeling and Atomic Force Microscopy”. PLoS ONE. 2011;6(4) :e18811.
- Milani P, Gholamirad M, Traas J, Arneodo A, Boudaoud A, Argoul F, Hamant O. “In vivo analysis of local wall stiffness at the Shoot Apical Meristem in Arabidopsis using atomic force microscopy”. Plant J, 2011;67(6):1116-1123.
- Milani P*, Moukhtar J*, Faivre-Moskalenko C*, Audit B, Vaillant C, Fontaine E, Mongelard F, Lavorel G, Saint-Jean P, Bouvet P, Argoul F, Arneodo A. “Atomic force microscopy experiment confirm that genomic long-range correlations reduce DNA persistence length”. J. Phys. Chem. 2010;114(15):5125-5143. (*co-first-authors)
- Milani P, Chevereau G, Vaillant C, Audit B, Haftek-Terreau Z, Marilley M, Bouvet P, Argoul F, Arneodo A. “Nucleosome positioning by excluding genomic energy barriers”. Proc. Natl. Acad. Sci. USA. 2009;106(52):22257-22262.
- Milani P, Marilley M, Rocca-Serra J. “TBP binding capacity of the TATA box is associated with specific structural properties: AFM study of the IL2RA gene promoter”. Biochimie. 2007;89(4):528-533.
- Marilley M, Milani P, Rocca-Serra J, Baldacci G. “Gradual melting of a replication origin (Schizosaccharomyces pombe ars1): in situ atomic force microscopy (AFM) analysis”. Biochimie. 2007;89(4):534-541 13.
- Marilley M, Milani P, Thimonier J, Rocca-Serra J. “DNA structure in replication initiation: Atomic Force Microscopy in liquid and DNA modelling of the Schizosaccharomyces pombe ars1 origin”. Nucleic Acid Res. 2007;35(20):6832-6845.
Pascale Milani, PhD
Co-Founder
Julien Chlasta, PhD
Co-Founder
