DermoMeca proposes to study physical behavior of fibroblasts, cells responsible for collagen and elastin synthesis, and dermis sustaining capacity.
- in vitro models: cells grown on collagen lattice
- ex vitro models: reconstructed skin models, skin explants, etc.
- Visualization and quantification of the mechanical activity of fibroblasts
- Organization of the collagen network
Light on our solutions
How daily exposure to blue light accelerates skin aging in impacting dermis mechanical properties ?
Light is necessary for life, but long exposure to artificial light is becoming a major health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs) found in screens and smartphones which can interfere with biological processes.
How to evaluate production of extracellular matrix components?
Collagen is one of the major constituents of dermis, the intermediate layer of skin. It is one of the most abundant protein in human and is composed of long polypeptide chains also called procollagene. These can also form fibrils when tropocollagene molecules are close to each other. In all tissues, these fibers then bind together to form a collagen structure and network that notably provides stiffness/firmness to the skin.