Cosmetics

DermoMeca reveals mechanical effects of your active ingredients and finished products on skin models. More than a claim, it’s a quasi-physiological proof.

A team and tool dedicated to your R&D projects 

Our in vitro and ex vivo tests allow you to innovate by bringing a biomechanical dimension to your cosmetic claims. Biophysics, imaging and skin biology : expertise adapted to all challenges of dermocosmetics.

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Case study

Blue light protection

Light is necessary for life, but long exposure to artificial light is becoming a major health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs) found in screens and smartphones which can interfere with biological processes.

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Case study

Skin barrier

Epidermal differenciation triggers to the formation of apoptotic cells, corenocytes more or less cohesive. One of the main role of these cells is to regulate epidermis permeability. The skin barrier is due to the accumulation of lipids (free fatty acids, cholesterol, ceramides) inside intercorneocytic spaces organized in stacks. This lipid matrix acts as a cement in the cell-cell cohesion and has a crucial rôle in protecting skin.

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Tensing effect

The dermis is largely composed of dense collagen-rich extracellular matrix (ECM). Dermal collagen represents by far the most abundant ECM protein and constitutes the bulk of skin. Dermal connective tissue collagen is essentially responsible for the skin’s tensile strength and mechanical properties.

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Case study

Hair protection

Hair is a constant victim of many agressions : water, sun, brushing, pollution, having shine and smooth hair with blow dryers and heating irons… The robust structure of its external layer, the cuticle, protects it. But as fantastic is this cuticle, we need to care of it… Hair robustness comes from the cortex structure but its permeability, brightness, softness or even manageability arise from cuticle condition.

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Beyond BioMechanics, there is mechanotransduction

All living cells depend on their mechanical surroundings. Their structure and function are directly linked to this mechanical stimulus (shear stress, gravity). Cells sense these physical forces by their integrin-based adhesion (“outside-in” and “inside-out”) and translate t
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10 June 2020