How to study active ingredient penetration in skin ?

In cosmetic industry and more generally in chemical formulation, it is important to understand active ingredients effects and how far they penetrate the different skin layers.

 

DermoMeca®’s solutions

DermoMeca® shows how epifluorescence microscopy helps to follow up an active ingredient during skin penetration. An excellent tool to screen active ingredients or optimize formulations.

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Case studies

Skin barrier

Epidermal differenciation triggers to the formation of apoptotic cells, corenocytes more or less cohesive. One of the main role of these cells is to regulate epidermis permeability. The skin barrier is due to the accumulation of lipids.
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Smoothing effect

Skin mobilization is the result of the different mobility capacities of the skin and its underlying structures. When the skin is stretched and mobilized, there is an elastic restoring force opposite to the axis of tension,which tends to return the skin to its previous state.
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Tensing effect

The dermis is largely composed of dense collagen-rich extracellular matrix (ECM). Dermal collagen represents by far the most abundant ECM protein and constitutes the bulk of skin.
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