How to prove smoothing effect of active ingredient or finished product ex vivo ?

Skin mobilization is the result of the different mobility capacities of the skin and its underlying structures.

When the skin is stretched and mobilized, there is an elastic restoring force opposite to the axis of tension, which tends to return the skin to its previous state. From these opposing forces, tension and stress forces arise.

DermoMeca®’s solutions

DermoMeca® proposes to study tissue tension with confocal microscopy, in analysing fluorescent beads movements after topical application of a product. 

Biological model : skin section

Readouts :

• Fluorescent beads position images at different times
• Analytical and vectorial images of bead displacement
• Graphic conclusion on the tensor effect of the product

Figure 1: Effect of product’s topical application of tension induced by it on epidermal surface (images of the fluorescent beads movement at different times).

Left: after application of the serum 24 hours later. Right: control 24 hours later.