Case studies
Empowering skin studies with precision profiling of corneocytes
Corneocytes are the outermost layer of the skin, composing the stratum corneum, which acts as a protective barrier. A fast profiling of corneocytes collected from volunteers or skin biopsies helps to select efficient cosmetic formulas…
See the study
Case studies
How UVA alters mechanical characteristics of the stratum corneum and dermis
Even though is nice to get some sun light, do you really know how UVA works on your skin? Read our entire case study so you know the impacts of UVA in your cutaneous skin barrier.
See the study
Case studies
Facial pores
Skin harbors two types of pores: sweat pores, linked to sweat glands, and visible pores being part of pilosebaceous units, containing hair follicle, associated to sebaceous glands…
See the study
Case studies
Collagen disks
The force of contraction of cells plays an important role in many processes such as healing, aging. Collagen is one of the main constituents of the dermis, forming a network of fibers that gives the skin its rigidity…
See the study
Case studies
Blue light
Light is necessary for life, but long exposure to artificial light is becoming a major health concern.
See the study
Case studies
Facemasks
The use of beauty masks re-emerges as the need of well-being increased during the pandemic crisis. More than relaxing time and wellbeing, consumers expectations have changed too and there is a strong demand on the safety and the efficacy of cosmetic products…
See the study
Case studies
Anti-aging and regenerating effect
Skin is the largest organ in the human body and represents our first barrier against external stress but also undergoes internal stress, such as intrinsic aging…
See the study
Case studies
Tissue stiffness
Pancreatic cancer is the 4th most frequent cause of cancer-related deaths worldwide and should become the 2nd one hence 2030. The extracellular matrix in the tumor microenvironment modulates the cancer cell phenotype and need to be more studied to develop efficient treatment
See the study
Case studies
Skin penetration
In cosmetic industry and more generally in chemical formulation, it is important to understand active ingredients effects and how far they penetrate the different skin layers.
See the study
Case studies
Skin disorders
The main barrier of the skin is located in the outermost layer of the skin, the stratum corneum. Several damages in stratum corneum involve skin barrier disorders as Atopic Dermatitis, complex disease due to multiple factors (immunologic, genetic, environnemental).
See the study
Case studies
Skin barrier
Epidermal differenciation triggers to the formation of apoptotic cells, corenocytes more or less cohesive. One of the main role of these cells is to regulate epidermis permeability. The skin barrier is due to the accumulation of lipids.
See the study
Case studies
Hair protection
Hair is a constant victim of many agressions : water, sun, brushing, pollution, having shine and smooth hair with blow dryers and heating irons… The robust structure of its external layer, the cuticle, protects it.
See the study
Case studies
Evaluation of production of extracellular matrix components
Collagen is one of the major constituents of dermis, the intermediate layer of skin. It is one of the most abundant protein in human and is composed of long polypeptide chains also called procollagene.
See the study
Case studies
Tensing effect
The dermis is largely composed of dense collagen-rich extracellular matrix (ECM). Dermal collagen represents by far the most abundant ECM protein and constitutes the bulk of skin.
See the study
Case studies
Plumping effect
Should skin pumpling a synonym to collagen production ? Yes certainly but not only. Stimulating microcirculation, moisturizing, nourishing are also effects to promote.
See the study
Case studies
Slimming effect
A slimming cream might have several actions depending on its target. It can regulate and balance storage and removal of fat. In this context, studying adipocytes, the responsible cells for fat storage in adipoe tissue, sheds light on its action’s mode.
See the study
Case studies
Smoothing effect
Skin mobilization is the result of the different mobility capacities of the skin and its underlying structures. When the skin is stretched and mobilized, there is an elastic restoring force opposite to the axis of tension,which tends to return the skin to its previous state.
See the study
Case studies
Tumor escape and extracellular matrix
A new dependence receptors family (DR) has been discovered by one of our academic partner. These receptors inhibit tumor progression by inducing apoptosis when cancer cells are in absence of DR ligands.
See the study
Case studies
Binding proteins characterization
To characterize a transmembrane protein by High Resolution Imaging and localize its binding sites, BioMeca® provides 2 solutions.
See the study
Case studies
Wound healing
Wound healing is a very complex process, specific to every organism and tissue, and addresses several factors and different cellular and tissular groups.
See the study
Case studies
Spheroids
Spheroids as microtissues are a powerful alternative to standard 2D cell culture for in vitro studies. 3D scaffold-free spheroids are formed within a few days from a cell suspension using hanging drop technology.
See the study