Gaël Runel, Jean-André Lapart, Julien Chlasta
Abstract
Human skin is submitted to various factors leading to either extrinsic or intrinsic aging. In addition to inducing molecular and morphological changes, skin aging is characterized by modifications in skin biomechanical properties modifications. These modifications can be used as biomarkers to both evaluate the degree of advancement in skin aging but also to detect potential pathologies. Hence, it is from critical interest to be able to evaluate skin biomechanical properties to fully detect and monitor these alterations. Here we introduce a portable and innovative device, EASYSTIFF®, which is thought to in vivo measure stiffness properties of skin. Based on indentation principle, EASYSTIFF® allows to identify both global stiffness of skin (all confounded cutaneous compartment) or compartmentalized stiffness, in which stiffness values of each compartment, i.e., the stratum corneum, the epidermis, the dermis and the hypodermis, are separately analyzed. Thus, EASYSTIFF® is a complementary tool to 2D and 3D in/ex vivo model and an alternative to existing devices that measure skin mechanical properties, for assessing the effectiveness of cosmetic products, monitoring skin stiffness over time and to provide better understanding in the evolution of skin mechanical properties.
Interested in this scientific publication?Download the full version!
Discover our other publications
Stiffness measurement is a biomarker of skin aging in vivo
Runel G, Cario M, Lopez-Ramirez N, Malbouyres M, Ruggiero F, Bernard L, Puisieux A, Caramel J, Chlasta J, Masse I.
Biomechanical Properties of Cancer Cells
Gradient in cytoplasmic pressure in germline cells controls overlying epithelial cell morphogenesis
Lamiré L-A, Milani P, Runel G, Kiss A, Arias L, Vergier B, de Bossoreille S, Das P, Cluet D, Boudaoud A, Grammont M. November 30, 2020.
Gene profile of zebrafish fin regeneration offers clues to kinetics, organization and biomechanics of basement membrane
Nauroy P, Guiraud A, Chlasta J, Malbouyres M, Gillet B, Hughes S, Lambert E, Ruggiero F. Matrix Biology
Changes in nano-mechanical properties of human epidermal cornified cells depending on their proximity to the skin surface
Milani P, Chlasta J, Abdayem R, Kezic S, Haftek M. J Mol Recognit. 22 mai 2018;e2722.
Variations in basement membrane mechanics are linked to epithelial morphogenesis
Chlasta J, Milani P, Runel G, Duteyrat JL, Arias L, Lamiré LA, Boudaoud A, Grammont M. Development 2017 : doi: 10.1242/dev.152652
Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer
Goehrig D, Nigri J, Samain R, Wu Z, Cappello P, Gabiane G, Zhang X, Zhao Y, Kim IS, Chanal M, Curto R, Hervieu V, de la Fouchardière C, Novelli F, Milani P, Tomasini R, Bousquet C, Bertolino P, Hennino A.