Pharmacology

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A cutting-edge technological platform combined with an expertise in biophysics and biology to offer you unique support in accomplishment of your projects

A TEAM AND TOOLS DEDICATED TO YOUR R&D PROBLEMS

One of the main challenges in development of new therapies is to understand the biological mechanisms involved in pathologies. The solution developed by BioMeca in pharmacology helps you to understand these action’s mechanisms and reveals the therapeutic effect of your molecules and products.

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Case study

Tumor escape and extracellular matrix

A new dependence receptors family (DR) has been discovered by one of our academic partner. These receptors inhibit tumor progression by inducing apoptosis when cancer cells are in absence of DR ligands. Due to the frequent inactivation of their apoptotic function in human cancers, DRs are now considered as tumor suppressors.

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Case study

Skin disorders

The main barrier of the skin is located in the outermost layer of the skin, the stratum corneum. Several damages in stratum corneum involve skin barrier disorders as Atopic Dermatitis, compex disease due to multiple factors (immunologic, genetic, environnemental). During formation of the stratum corneum barrier, terminally differentiated keratinocytes continue their maturation process within the dead superficial epidermal layer. 

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Case study

Tissue stiffness

Pancreatic ductal adenocarcinoma (PDAC) is the fourth most frequent cause of cancer-related deaths worldwide and should become the second one hence 2030. The extracellular matrix (ECM) in the tumor microenvironment modulates the cancer cell phenotype, especially in pancreatic ductal adenocarcinoma (PDAC), a tumor characterized by an intense desmoplastic reaction. PDAC is characterized by an intense “desmoplastic reaction”, consisting of the abnormal accumulation of ECM components, mostly collagen fibers.

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How’s AFM a fantastic tool in cancer research ?

Atomic Force Microscopy (AFM) allows studies of biological samples and molecules with atomic resolution under near-physiological condition. Cells, under external stimuli or any physiological modifications, bear physicochemical properties changes that directly affect…
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1 April 2020

Stress and strain

Our body, our organs, ours cells are submitted to mechanical stress. The influence of mechanical stress of living organisms is omnipresent. It depends not only on environmental and endogenous loads (pressure exerted by cavities and blood) but also on intrinsic mechanical…
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8 July 2019

Biomechanics to unravel the mystery of tissue regeneration

In collaboration with Florence Ruggiero’s team, we demonstrated how ColXIV-A regulates the checkerboard basement membrane organization and its biomechanics. Gene profile of zebrafish fin regeneration offers clues to kinetics, organization and biomechanics of basement…
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31 October 2018